生產系統

轉基因 CHO-S 細胞

轉基因蠶生產系統

提純材料

CHO-S 細胞培養上清

蠶蛹蛋白

產品等級

實驗研究用* *有臨床用級別

實驗研究用

導入基因

人層粘連蛋白 511-E8 片段

純度

95% 以上

濃度

0.5 mg/mL

解離常數

10 nM 以下

使用期限

生產后 2 年內

iPS 細胞培養能力

添加 0.5 μg/cm² 到培養容器中，可用于 iPS 細胞的維持培養

385-07361

892011

iMatrix-511 solution

(0.5 mg/mL)

層粘連蛋白511-E8片段，

溶液（0.5 mg/mL）

175 μg×2（350 μL×2)

381-07363

892012

175 μg×6（350 μL×6)

iMatrix-511

自生產后兩年內

iMatrix-511silk

自生產后兩年內

iMatrix-511MG

自生產后兩年內

人多能干細胞（hPSC）的確立

Miyazaki et al. Nat. Commun.3:1236, (2012)

證實用作hPSC的培養基質的有效性

Nakagawa et al. Sci. Rep. 4:3594, (2014)

確立醫療等級的hPSC

Takashima et al. Cell.158(6):1254-69, (2014)

促進向hPSC的基質狀態的轉移

Miyazaki et al. Sci. Rep.7:41165, (2017)

采用無需涂層操作的添加法培養hPSC

Sekine et al. Stem Cell Res.24:40-43, (2017)

確立疾病特異性的hPSC

Tan et al. Stem Cell Res. 24:12-15, (2017)

Ishida et al. Sci. Rep. 8(1), 310, (2018)

利用hPSC的基因編輯建立遺傳性疾病模型

Kim et al. Nature Communications, 9(1), 939, (2018)

Sakai-Takemura et al. Sci. Rep, 8, 6555, (2018)

懸浮培養由hPSC分化的肌肉前體細胞

由hPSC分化衍生的細胞

Doi et al. Stem Cell Reports. 2(3):337-50, (2014)

多巴胺產生神經元

Ishikawa et al. Hum. Mol. Genet.25(23):

5188-5197, (2016)

Nishimura et al. Stem Cell Reports.6(4):

511-524, (2016)

Samata et al. Nat. Commun. 7:13097, (2016)

Kikuchi et al. Nature. 548(7669):592-596, 　　(2017)

Morizane et al. Nat. Commun.8(1):385, (2017)

Kikuchi et al. J. Neurosci. Res.95(9):1829-37, (2017)

Goparaju et al. Sci. Rep. 7:42367, (2017)

運動神經元

Burridge et al. Nat. Methods.11(8):855-60, 　  (2014)

心肌細胞

Sougawa et al. Sci. Rep,8(1), 3726, (2018)

Yamauchi et al. BBRC, 495(1), 1278-1284, 　    (2018)

心室肌細胞

Akiyama et al. Sci. Rep, 8(1), 1189, (2018)

骨骼肌細胞

Saito et al. Stem Cell Res Ther, 9(1), 12, (2018)

成骨細胞

Uchimura et al. Stem cell research, 25, 98-106, (2017)

成肌細胞

Hayashi et al. Nature.531(7594):376-80, (2016)

視覺細胞

Hayashi et al. Nat. Protoc.12(4):683-696, (2017)

角膜上皮細胞

Takayama et al. BBRC. 474(1):91-96, (2016)

膽管上皮細胞

Takayama et al. Hepatol Commun,1(10), 1058-1069, (2017)

肝實質細胞

Takayama et al. Biomaterials, (2018)

Takebe et al. Cell Reports, 21(10), 2661-2670, (2017)

肝細胞

Tan et al. Stem Cell Reports, 11:1-11, (2018)

Camp et al. Nature. 546(7659):533-38, (2017)

定形內胚層細胞

Zhang et al. Stem Cell Reports, 10(2), 1–14, (2018)

后內胚層前體細胞

Tanigawa et al. Cell reports, 15(4), 801-813, (2016)

腎單位前體細胞（胎腎細胞）

Musah et al. Nat.Biomed.Eng.1:0069, (2017)

腎小球上皮細胞

Musah et al. Nature protocols,13(7):1662, 　  (2018)

Mae et al. BBRC, 495(1), 954-961, (2018)

輸尿管芽組織

Oshima et al. BBRC, 497(2), 719-725, (2018)

血細胞?血管內皮常見前體細胞

Taguchi et al. Cell Stem Cell, 21, (2017) 

*培養hPSC用于分化腎單位前體細胞（胎腎細胞）

Kawamura et al. Stem Cell Reports.6(3):312-20,(2016)

*培養hPSC用于分化心肌細胞

Sasaki et al. Cell Stem Cell.17(2):178-94, (2015)

*培養hPSC用于分化生殖細胞

Kojima et al. Cell Stem Cell.21(4):517-532, 　  (2017)

Furuta et al. PLoS One. 9(12):e112291, (2014)

*培養hPSC用于分化間充質細胞

人原代細胞的培養

Okumura et al. Invest. Ophth. Vis. Sci.56(5):2933-42, (2015)

人角膜內皮細胞

Hongo et al. Invest. Ophth. Vis. Sci.58(9):3325-34, (2017)

Polisetti et al. Sci. Rep.7(1):5152, (2017)

人角膜邊緣上皮前體細胞

Ishii et al. Stem Cell Reports, 10, 1-15, (2018)

衛星細胞

層粘連蛋白-整合素相互作用的分子機制

Ido et al. J. Biol. Chem. 282(15): 11144-54, 　  (2007)

Ido et al. J. Biol. Chem.283(42): 28149-57, 　  (2008)

Taniguchi et al. J. Biol. Chem. 284(12): 7820-31, (2009)

Taniguchi et al. BBRC.487(3): 525-531, (2017)

Takizawa et al. Sci Adv.3(9) :e1701497, (2017)

[2]

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of human induced pluripotent stem cells into mature kidney podocytes and establishment of a 

lomerulus Chip. Nature protocols, 13(7), 1662, (2018)

[3]

Ishii, K., Sakurai, H., Suzuki, N., Mabuchi, Y., Sekiya, I., Sekiguchi, K., Akazawa, C.. Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro. Stem Cell 

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[4]

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randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in 

human cells. Scientific Reports, 8(1), 310, (2018)

[5]

Takayama, K., Hagihara, Y., Toba, Y., Sekiguchi, K., Sakurai, F., Mizuguchi, H.. Enrichment of high-

functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. 

Biomaterials, (2018)

[6]

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combining RNA-based MYOD1-expression and POU5F1-silencing. Scientific Reports, 8(1), 1189, (2018)

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Sakamoto, T., Yamaguchi, A., Sueishi, K., Azuma, T.. Targeted reversion of induced pluripotent 

stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat 

calvarial bone defect model. Stem Cell Research & Therapy, 9(1), 12, (2018)

[8]

Yamauchi, K., Li, J., Morikawa, K., Liu, L., Shirayoshi, Y., Nakatsuji, N., Elliott, A. D., Hisatome, I., 

Suemori, H..Isolation and characterization of ventricular-like cells derived from NKX2-5 eGFP/w 

and MLC2v mCherry/w double knock-in human pluripotent stem cells. Biochemical and 

Biophysical Research Communications, 495(1), 1278-1284, (2018)

[9]

Mae, S., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., Okumura, S., Shibasaki, A., Osafune, K.. Generation of branching ureteric bud tissues from human pluripotent stem cells. 

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[10]

Kagihiro, M., Fukumori, K., Aoki, T., Ungkulpasvich, U., Mizutani, M., Viravaidya-Pasuwat, K.,& 

Kino-oka, M.. Kinetic analysis of cell decay during the filling process: Application to lot size 

determination in manufacturing systems for human induced pluripotent and mesenchymal stem cells. Biochemical Engineering Journal, 131, 31-38, (2018)

[11]

Zhang, R. R., Koido, M., Tadokoro, T., Ouchi, R., Matsuno, T., Ueno, Y., Sekine, K., Takebe, T., 

Taniguchi, H.. Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of 

Forming Gut and Liver Organoids. Stem Cell Reports, 10(2), 1?14, (2018)

[12]

Oshima, K., Saiki, N., Tanaka, M., Imamura, H., Niwa, A., Tanimura, A., Nagahashi, A., Hirayama, A., Okitac, K., Hotta, A., Kitayama, S., Osawa, M., Kaneko, S., Watanabe, A., Asaka, I., Fujibuchi, W., 

Imai, K., Yabe, H., Kamachi, Y., Hara, J., Kojima, S., Tomita, M., Soga, T., Noma, T., Nonoyama, S., 

Nakahata, T., Saito, MK.. Human AK2 links intracellular bioenergetic redistribution to the fate of 

hematopoietic progenitors. Biochemical and Biophysical Research Communications, 497(2), 719-

725, (2018)

[13]

Sougawa, N., Miyagawa, S., Fukushima, S., Kawamura, A., Yokoyama, J., Ito, E., Harada, A., 

Okimoto, K., Mochisuki-Oda, N., Saito, A., Sawa, Y.. Immunologic targeting of CD30 eliminates 

tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy. Scientific Reports, 8(1), 3726, (2018)

[14]

Yasuda, S. Y., Ikeda, T., Shahsavarani, H., Yoshida, N., Nayer, B., Hino, M., Vartak-Sharma, N.,

Suemori, H., Hasegawa, K.. Chemically defined and growth-factor-free culture system for the 

expansion and derivation of human pluripotent stem cells. Nature Biomedical Engineering, 2(3), 

173, (2018)

[15]

Kim, S. I., Matsumoto, T., Kagawa, H., Nakamura, M., Hirohata, R., Ueno, A., Ohishi, M., Sakuma, T., Soga, T., Yamamoto, T., Woltjen, K.. Microhomology-assisted scarless genome editing in human 

iPSCs. Nature Communications, 9(1), 939, (2018)

[16]

Hayashi, R., Ishikawa, Y., Katori, R., Sasamoto, Y., Taniwaki, Y., Takayanagi, Tsujikawa, M., 

Sekiguchi, K., Quantock, A. J., Nishida, K. . Coordinated generation of multiple ocular-like cell 

lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nature 

Protocols, 12(4), 683-696, (2017)

[17]

Kikuchi, T., Morizane, A., Okita, K., Nakagawa, M., Yamakado, H., Inoue, H., Takahashi, R., 

Takahashi, J. . Idiopathic Parkinson's disease patient‐derived induced pluripotent stem cells 

function as midbrain dopaminergic neurons in rodent brains. Journal of Neuroscience Research, 

95(9),1829-37, (2017)

[18]

Miyazaki, T., Isobe, T., Nakatsuji, N., & Suemori, H. . Efficient Adhesion Culture of Human 

Pluripotent Stem Cells Using Laminin Fragments in an Uncoated Manner. Scientific Reports, 7

(41165), 1-8, (2017)

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Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Shigeru B. H. Ko & Minoru S. H. Ko. . Rapid 

differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding 

transcription factors. Scientific Reports, 7, 42367, (2017)

[20]

Musah, S., Mammoto, A., Ferrante, C. T., Jeanty, S.S., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., Fatanat-Didar, T., Koshy, S., Weaver, C. J., Church, M. G., 

Ingber, F. D. . Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute 

kidney glomerular-capillary-wall function on a chip. Nature Biomedical Engineering, 1 (0069), 

(2017)

[21]

Camp, J. G., Sekine, K., Gerber, T., Loeffler-Wirth, H., Binder, H., Gac, M., Kanton, S., Kageyama, J., Damm, G., Seehofer, D., Belicova, L., Barsacchi, M., Barsacchi, R., Okuda, R., Yoshizawa, E., Kimura, M., Ayabe, H., Taniguchi, H., Takebe, T., & Belicova, L.. Multilineage communication regulates 

human liver bud development from pluripotency. Nature, 546, 533-538, (2017)

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Polisetti, N., Sorokin, L., Okumura, N., Koizumi, N., Kinoshita, S., Kruse, F. E., and Schlotzer-

Schrehardt, U. Laminin-511 and-521-based matrices for efficient ex vivo-expansion of human 

limbal epithelial progenitor cells. Scientific Reports, 7, 5152, (2017)

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Hongo, A., Okumura, N., Nakahara, M., Kay, E. P., & Koizumi, N.. The Effect of a p38 Mitogen-

Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal 

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Taniguchi, Y., Li, S., Takizawa, M., Oonishi, E., Toga, J., Yagi, E., & Sekiguchi, K. Probing the acidic 

residue within the integrin binding site of laminin-511 that interacts with the metal ion-

dependent adhesion site of α6β1 integrin. Biochemical and Biophysical Research 

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patient with familial idiopathic basal ganglia calcification (IBGC) caused by a variant in SLC20A2 

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leucine-rich glioma inactivated 1 (LGI1). Stem Cell Research, (2017)

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Sato-Nishiuchi, R., Li, S., Ebisu, F., Sekiguchi, K.. Recombinant laminin fragments endowed with 

collagen-binding activity: A tool for conferring laminin-like cell-adhesive activity to collagen 

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Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., 

Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Parmar, M., Takahashi, J.. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease 

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Mechanistic basis for the recognition of laminin-511 by α6β1 integrin. Science Advances, 3(9), 

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Shiina, T., Ishigaki, H., Itoh, Y., Okita, K., Yamasaki, E., Doi, D., Onoe, H., Ogasawara, K., Yamanaka, S., and Takahashi, J. . MHC matching improves engraftment of iPSC-derived neurons in non-

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Takahashi, R., Inoue, H., Morita, S., Yamamoto, M., Okita, K., Nakagawa, M., Parmar, M., Takahashi, J. . human ips cell-derived dopaminergic neurons function in a primate Parkinson's disease 

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Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem 

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and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells. Cell 

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Uchimura, T., Otomo, J., Sato, M., Sakurai, H.. A human iPS cell myogenic differentiation system 

permitting high-throughput drug screening. Stem cell research, 25, 98-106, (2017)

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Sougawa, N., Miyagawa, S., Fukushima, S., Saito, A., Yokoyama, J., Kitahara, M., Harada, A., Sato-

Nishiuchi, R., Sekiguchi, K., Sawa, Y.. Novel Stem Cell Niches Laminin 511 Promotes Functional 

Angiogenesis Through Enhanced Stem Cell Homing by Modulating" Stem Cell Beds" in the Failed Heart.Circulation, 136(1), A15587, (2017)

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Samata, B., Doi, D., Nishimura, K., Kikuchi, T., Watanabe, A., Sakamoto, Y., Kakuta, J., Ono, Y.,& 

Takahashi, J.. Purification of functional human ES and iPSC-derived midbrain dopaminergic 

progenitors using LRTM1. Nature Communications, 7(13097), 1-11, (2016)

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Hayashi, R., Ishikawa, Y., Sasamoto, Y., Katori, R., Nomura, N., Ichikawa, T., Araki, S., Soma, T., 

Kawasaki, S., Sekiguchi, K., Tsujikawa, M., Nishida, K., & Quantock, A. J.. Co-ordinated ocular 

development from human iPS cells and recovery of corneal function. Nature, 531(7594), 376-380, (2016)

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Matsuno, K., Mae, S. I., Okada, C., Nakamura, M., Watanabe, A., Toyoda, T., Uchida, E., Osafune, K.. Redefining definitive endoderm subtypes by robust induction of human induced pluripotent 

stem cells.Differentiation; research in biological diversity, (2016)

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Nishimura, K., Doi, D., Samata, B., Murayama, S., Tahara, T., Onoe, H., & Takahashi, J.. Estradiol 

Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal 

Circuits via Activation of Integrin α5β1. Stem cell reports, 6(4), 511-524, (2016)

[41]

Takayama, K., Mitani, S., Nagamoto, Y., Sakurai, F., Tachibana, M., Taniguchi, Y., Sekiguchi,K., 

Mizuguchi, H.. Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells. Biochemical and biophysical research communications, 474(1), 91-96, (2016)

[42]

Kawamura, T., Miyagawa, S., Fukushima, S., Maeda, A., Kashiyama, N., Kawamura, A., Miki, K., 

Okita, K., Yoshida, Y., Shiina, T., Ogasawara, K., Miyagawa, S., Toda, K., Okuyama, H., Sawa,Y.. 

Cardiomyocytes derived from MHC-homozygous induced pluripotent stem cells exhibit reduced allogeneic immunogenicity in MHC-matched non-human primates. Stem cell reports, 6(3), 312-

320, (2016).

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Tanigawa, S., Taguchi, A., Sharma, N., Perantoni, A. O., & Nishinakamura, R.. Selective in vitro 

propagation of nephron progenitors derived from embryos and pluripotent stem cells. Cell 

reports, 15(4), 801-813, (2016)

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Okumura, N., Kakutani, K., Numata, R., Nakahara, M., Schlotzer-Schrehardt, U., Kruse, F., Kinoshita. K., Koizumi, N.. Laminin-511 and-521 Enable Efficient In Vitro Expansion of Human Corneal 

Endothelial CellsLaminin-511 and-521 Enable Expansion of HCECs. Investigative ophthalmology & visual science, 56(5), 2933-2942, (2015)

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Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., 

Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., Saitou, M.. Robust in vitro 

induction of human germ cell fate from pluripotent stem cells. Cell stem cell, 17(2), 178-194, 

(2015)

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Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., & Yamanaka, S. . A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem 

cells. Scientific reports, 4(3594), 1-7, (2014)

[47]

Doi, D., Samata, B., Katsukawa, M., Kikuchi, T., Morizane, A., Ono, Y., Sekiguchi, K., Nakagawa, M., Parmar, M., Takahashi, J.. Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation. Stem cell reports, 2(3), 337-350, (2014)

[48]

Takashima, Y., Guo, G., Loos, R., Nichols, J., Ficz, G., Krueger, F., Oxley, D., Santos, F., Clarke, J., 

Mansfield, W., Reik, W., Bertone, P., Smith, A.. Resetting transcription factor control circuitry 

toward ground-state pluripotency in human. Cell, 158(6), 1254-1269, (2014)

[49]

Fukuta, M., Nakai, Y., Kirino, K., Nakagawa, M., Sekiguchi, K., Nagata, S., Matsumoto, Y., 

Yamamoto, T., Umeda, K., Heike, T., Okumura, N., Koizumi, N., Sato, T., Nakahata, T., Saito, M., 

Otsuka, T., Kinoshita, S., Ueno, M., Ikeya, M., Toguchida, J. . Derivation of mesenchymal stromal 

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